How is Syphilis treated in Nepal?

The standard treatment for early Syphilis (primary, secondary, early latent) is a single intramuscular injection of Benzathine Penicillin G 2.4 million units. For late latent or unknown duration, three weekly injections are required. In penicillin allergy, Doxycycline may be used under specialist guidance.

How much does Syphilis treatment cost in Nepal?

A single dose of Benzathine Penicillin G costs approximately Rs. 4000-6000 in Kathmandu, plus Rs. 500-1,500 for injection administration and doctor fee. Follow-up blood tests (RPR/VDRL) cost Rs. 600 per test at our clinic, matching the price shown under Diagnostic Tests We Offer.

Can Syphilis be cured permanently?

Yes. When treated correctly with the appropriate dose of Benzathine Penicillin at the right stage, Syphilis is fully curable. However, blood tests (RPR/VDRL) may remain weakly positive for years, so follow-up is important to confirm adequate response.

Is the penicillin injection painful or risky?

The injection is given deep into the muscle and can be uncomfortable for a few minutes. Serious allergic reactions are rare but possible, which is why treatment must be given in a clinic with emergency facilities and by an experienced doctor.

Can syphilis be cured?

Yes, syphilis is completely curable with antibiotics, especially in the early stages. Penicillin G injection is the standard treatment. Late-stage syphilis can also be treated but may cause permanent damage.

What are the stages of syphilis?

Syphilis progresses through primary (painless sore/chancre), secondary (rash, fever, lymph node swelling), latent (no symptoms), and tertiary (serious organ damage) stages.

How is syphilis transmitted?

Syphilis is transmitted through direct contact with a syphilis sore during vaginal, anal, or oral sex. It can also be transmitted from mother to baby during pregnancy (congenital syphilis).

How accurate is the VDRL test?

VDRL is a screening test that is sensitive but not specific. False positives can occur. Positive VDRL results are confirmed with TPHA or FTA-ABS tests which are over 99% specific.

What happens if syphilis is untreated?

Untreated syphilis can progress to tertiary stage causing damage to the heart, brain, nerves, eyes, and blood vessels. It can be fatal. Early treatment prevents all complications.

Can syphilis come back after treatment?

Reinfection is possible if exposed again. Follow-up blood tests are recommended at 3, 6, and 12 months to confirm cure and check for reinfection.

What is the cost of syphilis treatment in Kathmandu?

Penicillin treatment costs approximately Rs. 4,000-6,000 per course. Doxycycline or Azithromycin alternatives cost Rs. 1,500-3,000. Follow-up testing is Rs. 500-600.

Is syphilis common in Nepal?

Syphilis remains a significant public health concern in Nepal, with cases reported across all provinces. Regular screening is recommended for sexually active individuals.

Can I get syphilis more than once?

Yes, having syphilis once does not provide immunity. You can be reinfected and should use prevention methods consistently.

How long does it take for syphilis symptoms to appear?

Primary syphilis symptoms appear 3-90 days after exposure (average 21 days). Secondary symptoms appear 2-12 weeks after the primary sore heals.

How many syphilis cases are reported in Nepal annually?

Nepal reports approximately 3,000-5,000 syphilis cases annually. Congenital syphilis remains a concern with 100-200 cases reported each year. The government recommends routine syphilis screening for all pregnant women as part of the national protocol.

Expert-Verified Syphilis Treatment Guide

Syphilis Treatment in Nepal:
Curable With Correct Penicillin Schedule

Name: STD Treatment Clinic
Address: Bhagwatibahal, Thamel, Kathmandu, Bagmati Province, 44600, NP
Telephone: +977-9700682800
Price range: NPR 450 - NPR 5000
Rating: 4.9

Detailed Syphilis treatment guide from Dr. G.P. Yadav (MD) in Kathmandu. Understand penicillin injection schedules, staging, costs, and follow-up testing.

[नेपाली] डा. जी.पी. यादव (एमडी), काठमाडौंबाट सिफिलिस उपचारको विस्तृत मार्गदर्शन। पेनिसिलिन इन्जेक्शन तालिका, रोगको चरण, लागत र फलो-अप रक्त परीक्षण बारे स्पष्ट जानकारी।

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Medically Reviewed

Expert Verified

Dr. G.P. YadavNMC: 15834

MBBSMD MedicineSTD Specialist

Reviewed: Jan 5, 2024

Updated: Jan 5, 2024

Clinical Observations in Nepal

In our Kathmandu clinic, Syphilis is frequently diagnosed at the secondary or latent stage. Many patients come only after a positive blood test done for visa, marriage, or HIV screening, without remembering any genital sore.

Early treatment with Benzathine Penicillin prevents long-term complications like neurosyphilis and heart disease.
Co-infection with HIV is not uncommon in Nepal, so combined screening is strongly recommended.
Many patients have taken incomplete antibiotics from pharmacies, which can change symptoms but does not cure the infection fully.

Treatment Protocols

Syphilis is treated according to stage. For early Syphilis (infection within 1 year), a single intramuscular dose of Benzathine Penicillin G 2.4 million units is used. For late latent or unknown duration, three weekly doses are required. The same medicine is available in Nepal and used as per international guidelines.

[नेपाली] सिफिलिसको उपचार रोगको चरण अनुसार हुन्छ। प्रारम्भिक सिफिलिस (१ वर्ष भित्रको संक्रमण) मा Benzathine Penicillin G को २.४ मिलियन युनिटको एक पटक मांसपेशीमा इन्जेक्शन दिइन्छ। ढिलो वा अवधि नथाहा भएको अवस्थामा हप्तामा एक पटक गरी ३ पटक इन्जेक्शन दिनुपर्छ। यही औषधि नेपालमा उपलब्ध छ र अन्तर्राष्ट्रिय मापदण्ड अनुसार प्रयोग हुन्छ।

Early Syphilis (Primary, Secondary, Early Latent)

Single intramuscular dose of Benzathine Penicillin G 2.4 million units. Abstain from sex for at least 7 days after treatment and until partners are treated.

Late Latent or Unknown Duration

Benzathine Penicillin G 2.4 million units intramuscular once weekly for 3 weeks (total 3 doses). Follow-up RPR testing at 6, 12, and 24 months.

Penicillin Allergy Options

Doxycycline 100mg twice daily for 14-28 days may be used in some cases, but requires strict adherence and close follow-up. Penicillin desensitization is preferred in pregnancy.

Neurosyphilis and Eye Syphilis

These require intravenous Penicillin in hospital under specialist care. We arrange referral and coordinate with neurology and ophthalmology teams when needed.

Follow-up Schedule and Blood Tests

After treatment, regular blood tests (RPR or VDRL) are essential to confirm cure. In Nepal, these tests are available in most major labs. We usually repeat tests at 3, 6, and 12 months, and sometimes longer for late Syphilis.

[नेपाली] उपचारपछि रोग निको भएको पुष्टि गर्न नियमित रक्त परीक्षण (RPR वा VDRL) अत्यन्त आवश्यक हुन्छ। नेपालका अधिकांश ठूला प्रयोगशालाहरूमा यी परीक्षण उपलब्ध छन्। हामी प्रायः ३, ६ र १२ महिनामा परीक्षण दोहोर्‍याउँछौं, ढिलो सिफिलिसमा अझ लामो समयसम्म निगरानी गर्नुपर्छ।

For early Syphilis, we expect at least a four-fold drop in RPR/VDRL titer within 12 months (for example, from 1:32 to 1:8).
For late Syphilis, the fall in titer is slower, but it should still gradually decline over 24 months.
Some patients remain “serofast” with a low positive titer despite adequate treatment. In such cases, the trend over time and clinical evaluation are more important than a completely negative report.

Treatment and Test Costs in Nepal

Typical Cost Range (Kathmandu)

Benzathine Penicillin G (2.4 million units)Rs. 4000-6000
Injection administration and clinic feeRs. 500-1,500
RPR/VDRL blood testRs. 600
HIV and Hepatitis screening packageRs. 1,500-3,000
Follow-up consultationRs. 450

Partner Notification and Prevention

All sexual partners from the last 3 months (for early Syphilis) or longer (for late Syphilis) should be informed, tested, and treated if necessary. We provide confidential partner notification support to reduce stigma and protect your relationships.

[नेपाली] प्रारम्भिक सिफिलिसमा कम्तीमा पछिल्ला ३ महिनाका र ढिलो सिफिलिसमा अझ लामो अवधिका सबै यौन पार्टनरलाई जानकारी गराई परीक्षण र आवश्यक परे उपचार गर्नुपर्छ। हामी गोपनीय पार्टनर सूचना सहयोग प्रदान गर्छौं जसले कलंक घटाउन र सम्बन्ध सुरक्षित राख्न मद्दत गर्छ।

Important Public Health Note

Treating partners is essential to prevent re-infection and to reduce the spread of Syphilis in Nepal. Untreated Syphilis can cause serious complications for you and your partners, especially during pregnancy.

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Last Updated: June 3, 2026 |Clinic: STD Treatment Clinic |License: 15834