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Male Sexual Dysfunction
Post-Orgasmic Illness Syndrome (POIS)
Post-Orgasmic Illness Syndrome is a rare condition where men experience severe flu-like symptoms including fatigue, feverishness, cognitive fog, and mood changes within minutes to hours after ejaculation. Symptoms persist for days.
50%
Success Rate
Symptoms last 2-7 days per episode; chronic condition with no cure
Duration
Multiple
Treatment Options
3+ Groups
May Affect
What is Post-Orgasmic Illness Syndrome (POIS)?
Post-Orgasmic Illness Syndrome is a rare condition where men experience severe flu-like symptoms including fatigue, feverishness, cognitive fog, and mood changes within minutes to hours after ejaculation. Symptoms persist for days.
Prevalence: Very rare; exact prevalence unknown; underdiagnosed condition
Symptoms and Signs
- •Extreme fatigue and exhaustion after ejaculation
- •Flu-like symptoms (fever, sweating, chills)
- •Brain fog and difficulty concentrating
- •Irritability and mood changes
- •Nasal congestion and watery eyes
- •Muscle aches and weakness
- •Social withdrawal during episodes
Causes and Risk Factors
Common Causes
- →Autoimmune reaction to seminal proteins
- →Allergic response to autologous semen
- →Neuroendocrine dysregulation
- →Cytokine release triggered by ejaculation
- →Psychological conditioning (proposed)
Risk Factors
- ⚠️Family history of autoimmune disorders
- ⚠️Allergic conditions
- ⚠️High frequency of ejaculation
- ⚠️Onset typically in young adulthood
Treatment Options
Expected Outcomes: Symptom reduction is variable; antihistamines help 30-50% of patients; no definitive cure
Available Treatments:
- ✓Antihistamines (H1 and H2 blockers) before ejaculation
- ✓NSAIDs to reduce inflammation
- ✓Immunotherapy with autologous semen (experimental)
- ✓Hormonal therapy
- ✓Selective serotonin reuptake inhibitors
- ✓Abstinence or reduced ejaculation frequency
- ✓Counseling and support groups
Prevention Tips
- →Reduce ejaculation frequency
- →Identify and avoid triggers
- →Antihistamine pre-treatment (under medical supervision)
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